PFKL Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway. Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade E sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC; Kinase, other
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component:  6-phosphofructokinase complex; cytosol; extracellular region; ficolin-1-rich granule lumen; secretory granule lumen
Molecular Function:  6-phosphofructokinase activity; ATP binding; fructose binding; fructose-6-phosphate binding; identical protein binding; kinase binding; metal ion binding; protein binding
Biological Process:  canonical glycolysis; fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; glycolytic process; negative regulation of insulin secretion; neutrophil degranulation; protein complex oligomerization; response to glucose
Reference #:  P17858 (UniProtKB)
Alt. Names/Synonyms: 6-phosphofructokinase, liver type; ATP-dependent 6-phosphofructokinase, liver type; DKFZp686G1648; DKFZp686L2097; FLJ30173; FLJ40909; K6PL; liver phosphofructokinase; liver-type 1-phosphofructokinase; PFK-B; PFKL; Phosphofructo-1-kinase isozyme B; Phosphofructokinase 1; phosphofructokinase, liver; Phosphohexokinase
Gene Symbols: PFKL
Molecular weight: 85,018 Da
Basal Isoelectric point: 7.26  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB