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ZNF24
a transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro. Belongs to the krueppel C2H2-type zinc-finger protein family. Expressed in many tissues except in heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 18q12.2 |
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Cellular Component:
nucleus
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Molecular Function:
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; sequence-specific DNA binding; zinc ion binding
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Biological Process:
myelination; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II
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Reference #:
P17028
(UniProtKB)
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Alt. Names/Synonyms: KOX17; lacks zinc finger domain; Retinoic acid suppression protein A; RSG-A; Zfp191; Zinc finger and SCAN domain-containing protein 3; Zinc finger protein 191; Zinc finger protein 24; zinc finger protein 24 (KOX 17); Zinc finger protein KOX17; ZNF191; ZNF24; ZSCAN3
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Gene Symbols: ZNF24
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Molecular weight:
42,155 Da
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Basal Isoelectric point:
5.82
Predict pI for various phosphorylation states
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