PKM Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages. Belongs to the pyruvate kinase family. Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 15q23
Cellular Component:  cilium; cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; nucleus; pyruvate kinase complex; secretory granule lumen
Molecular Function:  ADP binding; ATP binding; identical protein binding; kinase activity; magnesium ion binding; potassium ion binding; protein binding; pyruvate kinase activity; thyroid hormone binding
Biological Process:  animal organ regeneration; ATP biosynthetic process; canonical glycolysis; liver development; neutrophil degranulation; positive regulation of sprouting angiogenesis; programmed cell death; protein homotetramerization; pyruvate biosynthetic process; response to gravity; response to hypoxia; response to muscle inactivity; response to nutrient; skeletal muscle tissue regeneration
Reference #:  P14618 (UniProtKB)
Alt. Names/Synonyms: CTHBP; Cytosolic thyroid hormone-binding protein; epididymis secretory protein Li 30; HEL-S-30; KPYM; MGC3932; OIP-3; OIP3; Opa-interacting protein 3; p58; PK, muscle type; PK2; PK3; PKM; PKM2; Pyruvate kinase 2/3; Pyruvate kinase isozymes M1/M2; pyruvate kinase M1/2; Pyruvate kinase muscle isozyme; Pyruvate kinase PKM; pyruvate kinase, muscle; TCB; THBP1; Thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; Tumor M2-PK
Gene Symbols: PKM
Molecular weight: 57,937 Da
Basal Isoelectric point: 7.96  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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