MIF a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. Also acts as a phenylpyruvate tautomerase. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Apoptosis; Cell development/differentiation; Cytokine; EC 5.3.2.1; EC 5.3.3.12; Isomerase
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component:  cell surface; cytosol; extracellular region; extracellular space; ficolin-1-rich granule lumen; nucleoplasm; secretory granule lumen
Molecular Function:  chemoattractant activity; cytokine activity; cytokine receptor binding; dopachrome isomerase activity; identical protein binding; phenylpyruvate tautomerase activity; protease binding; protein binding; signaling receptor binding
Biological Process:  carboxylic acid metabolic process; cell aging; cell proliferation; cell surface receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; inflammatory response; innate immune response; interleukin-12-mediated signaling pathway; leukocyte migration; negative regulation of apoptotic process; negative regulation of cell aging; negative regulation of cell cycle arrest; negative regulation of cellular protein metabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of gene expression; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of macrophage chemotaxis; negative regulation of mature B cell apoptotic process; negative regulation of myeloid cell apoptotic process; neutrophil degranulation; positive chemotaxis; positive regulation of arachidonic acid secretion; positive regulation of B cell proliferation; positive regulation of chemokine (C-X-C motif) ligand 2 production; positive regulation of cytokine secretion; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of MAP kinase activity; positive regulation of myeloid leukocyte cytokine production involved in immune response; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; positive regulation of prostaglandin secretion involved in immune response; positive regulation of protein kinase A signaling; positive regulation of tumor necrosis factor production; prostaglandin biosynthetic process; protein homotrimerization; regulation of macrophage activation; regulation of signaling receptor activity
Disease: Rheumatoid Arthritis, Systemic Juvenile
Reference #:  P14174 (UniProtKB)
Alt. Names/Synonyms: GIF; GLIF; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; Macrophage migration inhibitory factor; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MIF; MMIF; Phenylpyruvate tautomerase
Gene Symbols: MIF
Molecular weight: 12,476 Da
Basal Isoelectric point: 7.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MIF

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB