L-plastin Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q14.13
Cellular Component:  actin cytoskeleton; actin filament; actin filament bundle; cell junction; cytoplasm; cytosol; filopodium; focal adhesion; phagocytic cup; plasma membrane; podosome; ruffle; ruffle membrane
Molecular Function:  actin binding; actin filament binding; calcium ion binding; GTPase binding; identical protein binding; integrin binding
Biological Process:  actin filament bundle assembly; animal organ regeneration; cell migration; extracellular matrix disassembly; interleukin-12-mediated signaling pathway; positive regulation of podosome assembly; protein kinase A signaling; regulation of intracellular protein transport; T cell activation involved in immune response
Reference #:  P13796 (UniProtKB)
Alt. Names/Synonyms: bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); CP64; DKFZp781A23186; FLJ25423; FLJ26114; FLJ39956; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); LC64P; LCP-1; LCP1; LPL; Lymphocyte cytosolic protein 1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; Plastin-2; PLS2; PLSL
Gene Symbols: LCP1
Molecular weight: 70,288 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene