HSP60 Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Interacts with HRAS. Interacts with HBV protein X and HTLV-1 protein p40tax. Belongs to the chaperonin (HSP60) family. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Mitochondrial
Chromosomal Location of Human Ortholog: 2q33.1
Cellular Component:  cell surface; clathrin-coated pit; cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; cytosol; early endosome; extracellular exosome; extracellular space; lipopolysaccharide receptor complex; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; plasma membrane; secretory granule
Molecular Function:  apolipoprotein A-I binding; apolipoprotein binding; ATP binding; ATPase activity; chaperone binding; DNA replication origin binding; double-stranded RNA binding; enzyme binding; high-density lipoprotein particle binding; lipopolysaccharide binding; p53 binding; protein binding; single-stranded DNA binding; ubiquitin protein ligase binding; unfolded protein binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; adhesion of symbiont to host; apoptotic mitochondrial changes; B cell activation; B cell cytokine production; B cell proliferation; chaperone-mediated protein complex assembly; de novo'protein folding; interaction with symbiont; isotype switching to IgG isotypes; mitochondrion organization; MyD88-dependent toll-like receptor signaling pathway; negative regulation of apoptosis; positive regulation of apoptosis; positive regulation of interferon-alpha production; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of macrophage activation; positive regulation of T cell activation; positive regulation of T cell mediated immune response to tumor cell; protein import into mitochondrial intermembrane space; protein maturation; protein refolding; protein stabilization; regulation of cytokine production; regulation of transcription from RNA polymerase II promoter; response to cold; response to unfolded protein; T cell activation; viral process
Disease: Leukodystrophy, Hypomyelinating, 4; Spastic Paraplegia 13, Autosomal Dominant
Reference #:  P10809 (UniProtKB)
Alt. Names/Synonyms: 60 kDa chaperonin; 60 kDa heat shock protein, mitochondrial; CH60; Chaperonin 60; CPN60; GROEL; heat shock 60kDa protein 1 (chaperonin); Heat shock protein 60; heat shock protein 65; HLD4; HSP-60; HSP60; HSP65; HSPD1; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; short heat shock protein 60 Hsp60s1; SPG13
Gene Symbols: HSPD1
Molecular weight: 61,055 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein