RPSA Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. (Microbial infection) Acts as a receptor for the Dengue virus. (Microbial infection) Acts as a receptor for the Sindbis virus. (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. (Microbial infection) Acts as a receptor for the pathogenic prion protein. (Microbial infection) Acts as a receptor for bacteria. Belongs to the universal ribosomal protein uS2 family. Note: This description may include information from UniProtKB.
Protein type: Ribosomal
Chromosomal Location of human Ortholog: 3p22.1
Cellular Component:  cytoplasm; cytosol; cytosolic small ribosomal subunit; nucleoplasm; nucleus; plasma membrane
Molecular Function:  laminin binding; laminin receptor activity; protein binding; ribosome binding; virus receptor activity
Biological Process:  cell adhesion; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral entry into host cell; viral transcription
Disease: Asplenia, Isolated Congenital
Reference #:  P08865 (UniProtKB)
Alt. Names/Synonyms: 37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67kD, ribosomal protein SA; 67LR; Colon carcinoma laminin-binding protein; ICAS; LAMBR; laminin binding protein; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); Laminin-binding protein precursor p40; LamR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; p40; ribosomal protein SA; RPSA; RSSA; SA; Small ribosomal subunit protein uS2
Gene Symbols: RPSA
Molecular weight: 32,854 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Select Structure to View Below

RPSA

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene