|
ACTB
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Belongs to the actin family. Note: This description may include information from UniProtKB.
|
| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 7p22.1 |
|
Cellular Component:
actin cytoskeleton; calyx of Held; cortical cytoskeleton; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; dense body; glutamatergic synapse; NuA4 histone acetyltransferase complex; nucleoplasm; nucleus; plasma membrane; postsynaptic actin cytoskeleton; presynapse; protein-containing complex; ribonucleoprotein complex; Schaffer collateral - CA1 synapse
|
|
Molecular Function:
ATP binding; identical protein binding; kinesin binding; nitric-oxide synthase binding; protein binding; protein kinase binding; structural constituent of cytoskeleton; structural constituent of postsynaptic actin cytoskeleton; Tat protein binding; tau protein binding
|
|
Biological Process:
cell junction assembly; cell motility; cellular response to cytochalasin B; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; membrane organization; negative regulation of protein binding; positive regulation of gene expression, epigenetic; positive regulation of norepinephrine uptake; postsynaptic actin cytoskeleton organization; protein deubiquitination; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of norepinephrine uptake; regulation of protein localization to plasma membrane; regulation of transmembrane transporter activity; synaptic vesicle endocytosis
|
|
Disease: Baraitser-winter Syndrome 1; Dystonia, Juvenile-onset
|
|
Reference #:
P60709
(UniProtKB)
|
|
Alt. Names/Synonyms: ACTB; actin beta; actin, beta; Actin, cytoplasmic 1; Actin, cytoplasmic 1, N-terminally processed; beta actin; beta cytoskeletal actin; Beta-actin; BRWS1; I(2)-actin; PS1TP5-binding protein 1; PS1TP5BP1
|
|
Gene Symbols: ACTB
|
|
Molecular weight:
41,737 Da
|
|
Basal Isoelectric point:
5.29
Predict pI for various phosphorylation states
|
|
CST Pathways:
Death Receptor Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
