ACTB Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7p22.1
Cellular Component:  actin cytoskeleton; calyx of Held; cortical cytoskeleton; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; dense body; glutamatergic synapse; NuA4 histone acetyltransferase complex; nucleoplasm; nucleus; plasma membrane; postsynaptic actin cytoskeleton; presynapse; protein-containing complex; ribonucleoprotein complex; Schaffer collateral - CA1 synapse
Molecular Function:  ATP binding; identical protein binding; kinesin binding; nitric-oxide synthase binding; protein binding; protein kinase binding; structural constituent of cytoskeleton; structural constituent of postsynaptic actin cytoskeleton; Tat protein binding; tau protein binding
Biological Process:  cell junction assembly; cell motility; cellular response to cytochalasin B; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; membrane organization; negative regulation of protein binding; positive regulation of gene expression, epigenetic; positive regulation of norepinephrine uptake; postsynaptic actin cytoskeleton organization; protein deubiquitination; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of norepinephrine uptake; regulation of protein localization to plasma membrane; regulation of transmembrane transporter activity; synaptic vesicle endocytosis
Disease: Baraitser-winter Syndrome 1; Dystonia, Juvenile-onset
Reference #:  P60709 (UniProtKB)
Alt. Names/Synonyms: ACTB; actin beta; actin, beta; Actin, cytoplasmic 1; Actin, cytoplasmic 1, N-terminally processed; beta actin; beta cytoskeletal actin; Beta-actin; BRWS1; I(2)-actin; PS1TP5-binding protein 1; PS1TP5BP1
Gene Symbols: ACTB
Molecular weight: 41,737 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB