| ACTB Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Belongs to the actin family. Note: This description may include information from UniProtKB. |
| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 7p22.1 |
| Cellular Component: actin cytoskeleton; actin filament; adherens junction; apical junction complex; axon; bBAF complex; brahma complex; brush border; calyx of Held; cell-cell junction; chromatin; cortical cytoskeleton; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; dense body; GBAF complex; glutamatergic synapse; kinetochore; lamellipodium; membrane; nBAF complex; npBAF complex; NuA4 histone acetyltransferase complex; nuclear matrix; nucleoplasm; nucleosome; nucleus; plasma membrane; postsynaptic actin cytoskeleton; presynapse; protein-containing complex; ribonucleoprotein complex; RSC-type complex; Schaffer collateral - CA1 synapse; SWI/SNF complex; synapse; tight junction |
| Molecular Function: ATP binding; hydrolase activity; identical protein binding; kinesin binding; nitric-oxide synthase binding; protein binding; protein kinase binding; structural constituent of cytoskeleton; structural constituent of postsynaptic actin cytoskeleton; Tat protein binding; tau protein binding |
| Biological Process: adherens junction assembly; apical protein localization; axonogenesis; cell motility; cellular response to cytochalasin B; chromatin remodeling; establishment or maintenance of cell polarity; histone acetylation; histone H2A acetylation; histone H4 acetylation; maintenance of blood-brain barrier; morphogenesis of a polarized epithelium; negative regulation of cell differentiation; negative regulation of protein binding; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair; positive regulation of double-strand break repair via homologous recombination; positive regulation of myoblast differentiation; positive regulation of norepinephrine uptake; positive regulation of stem cell population maintenance; positive regulation of T cell differentiation; postsynaptic actin cytoskeleton organization; protein localization to adherens junction; regulation of apoptotic process; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of double-strand break repair; regulation of G0 to G1 transition; regulation of G1/S transition of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of norepinephrine uptake; regulation of nucleotide-excision repair; regulation of protein localization to plasma membrane; regulation of synaptic vesicle endocytosis; regulation of transcription by RNA polymerase II; regulation of transepithelial transport; regulation of transmembrane transporter activity |
| Disease: Baraitser-winter Syndrome 1; Becker Nevus Syndrome; Congenital Smooth Muscle Hamartoma, With Or Without Hemihypertrophy; Desbuquois Dysplasia 2; Dystonia, Juvenile-onset; Thrombocytopenia 8, With Dysmorphic Features And Developmental Delay |
| Reference #: P60709 (UniProtKB) |
| Alt. Names/Synonyms: ACTB; actin beta; actin, beta; Actin, cytoplasmic 1; Actin, cytoplasmic 1, N-terminally processed; beta actin; beta cytoskeletal actin; Beta-actin; BRWS1; I(2)-actin; PS1TP5-binding protein 1; PS1TP5BP1 |
| Gene Symbols: ACTB |
| Molecular weight: 41,737 Da |
| Basal Isoelectric point: 5.29 Predict pI for various phosphorylation states |
| CST Pathways: Death Receptor Signaling |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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ACTB |
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| Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Reactome
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Protein Atlas
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BioGPS
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Pfam
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