ACTA1 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 1q42.13
Cellular Component:  actin cytoskeleton; actin filament; cell body; cytosol; filopodium; lamellipodium; sarcomere; stress fiber; striated muscle thin filament
Molecular Function:  ADP binding; ATP binding; myosin binding; protein binding; structural constituent of cytoskeleton
Biological Process:  cellular response to organonitrogen compound; mesenchyme migration; muscle contraction; muscle filament sliding; positive regulation of gene expression; response to extracellular stimulus; response to lithium ion; response to mechanical stimulus; response to steroid hormone; skeletal muscle fiber adaptation; skeletal muscle fiber development; skeletal muscle thin filament assembly
Disease: Myopathy, Congenital, With Fiber-type Disproportion; Myopathy, Scapulohumeroperoneal; Nemaline Myopathy 3
Reference #:  P68133 (UniProtKB)
Alt. Names/Synonyms: ACTA; ACTA1; actin alpha 1, skeletal muscle; actin, alpha 1, skeletal muscle; Actin, alpha skeletal muscle; Actin, alpha skeletal muscle, intermediate form; ACTS; alpha skeletal muscle actin; Alpha-actin-1; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3; nemaline myopathy type 3; SHPM
Gene Symbols: ACTA1
Molecular weight: 42,051 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ACTA1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene