| PGK1 In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. Belongs to the phosphoglycerate kinase family. Mainly expressed in spermatogonia. Localized on the principle piece in the sperm (at protein level). Expression significantly decreased in the testis of elderly men. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; Kinase, other |
| Chromosomal Location of human Ortholog: Xq21.1 |
| Cellular Component: cytosol; extracellular space; membrane raft |
| Molecular Function: ADP binding; ATP binding; phosphoglycerate kinase activity; protein binding; protein-disulfide reductase (NAD(P)) activity |
| Biological Process: canonical glycolysis; cellular response to hypoxia; epithelial cell differentiation; gluconeogenesis; glycolytic process; negative regulation of angiogenesis; phosphorylation; plasminogen activation |
| Disease: Phosphoglycerate Kinase 1 Deficiency |
| Reference #: P00558 (UniProtKB) |
| Alt. Names/Synonyms: Cell migration-inducing gene 10 protein; epididymis secretory sperm binding protein Li 68p; HEL-S-68p; MGC117307; MGC142128; MGC8947; MIG10; PGK1; PGKA; Phosphoglycerate kinase 1; Primer recognition protein 2; PRP 2 |
| Gene Symbols: PGK1 |
| Molecular weight: 44,615 Da |
| Basal Isoelectric point: 8.3 Predict pI for various phosphorylation states |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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PGK1 |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Reactome
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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