GSR Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 5 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.8.1.7; Other Amino Acids Metabolism - glutathione; Oxidoreductase
Chromosomal Location of human Ortholog: 8p12
Cellular Component:  cytosol; external side of plasma membrane; mitochondrial matrix
Molecular Function:  electron transfer activity; NADP binding
Biological Process:  cellular oxidant detoxification; cellular response to oxidative stress; electron transport chain; nucleobase-containing small molecule interconversion
Disease: Hemolytic Anemia Due To Glutathione Reductase Deficiency
Reference #:  P00390 (UniProtKB)
Alt. Names/Synonyms: epididymis luminal protein 75; epididymis secretory sperm binding protein Li 122m; GLUR; glutathione reductase; Glutathione reductase, mitochondrial; glutathione S-reductase; glutathione-disulfide reductase; GR; GRase; GRD1; GSHR; GSR; GSRD; HEL-75; HEL-S-122m; MGC78522
Gene Symbols: GSR
Molecular weight: 56,257 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Select Structure to View Below

GSR

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB