IPO7 Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. (Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev. Belongs to the importin beta family. Note: This description may include information from UniProtKB.
Protein type: Karyopherin; Nuclear export; Nuclear import
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component:  cytosol; nuclear pore; nucleoplasm
Molecular Function:  GTPase regulator activity; histone binding; protein binding; Ran GTPase binding; SMAD binding
Biological Process:  innate immune response; negative regulation of cyclin-dependent protein serine/threonine kinase activity; signal transduction; viral process
Reference #:  O95373 (UniProtKB)
Alt. Names/Synonyms: FLJ14581; Imp7; importin 7; Importin-7; IPO7; MGC138673; Ran-binding protein 7; RANBP7
Gene Symbols: IPO7
Molecular weight: 119,517 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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