CGRP-RCP DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway. Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. Belongs to the eukaryotic RPC9 RNA polymerase subunit family. Ubiquitous. Most prevalent in testis. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q11.21
Cellular Component:  acrosomal vesicle; cell; cytosol; DNA polymerase III complex; nucleoplasm; plasma membrane
Molecular Function:  calcitonin gene-related peptide receptor activity; DNA-directed 5'-3' RNA polymerase activity; nucleotide binding; protein binding
Biological Process:  defense response to virus; innate immune response; neuropeptide signaling pathway; positive regulation of type I interferon production; transcription by RNA polymerase III
Reference #:  O75575 (UniProtKB)
Alt. Names/Synonyms: C17; Calcitonin gene-related peptide-receptor component protein; CGRP receptor component; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; CRCP; DNA-directed RNA polymerase III subunit RPC9; HsC17; MGC111194; POLR3I; POLR3J; RCP; RCP9; RNA polymerase III subunit C9; RPC9
Gene Symbols: CRCP
Molecular weight: 16,871 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein