GMD Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; EC 4.2.1.47; Lyase
Chromosomal Location of Human Ortholog: 6p25.3
Cellular Component:  cytoplasm; cytosol
Molecular Function:  GDP-mannose 4,6-dehydratase activity; identical protein binding; NADP+ binding; protein binding
Biological Process:  'de novo' GDP-L-fucose biosynthetic process; GDP-mannose metabolic process; Notch signaling pathway
Reference #:  O60547 (UniProtKB)
Alt. Names/Synonyms: GDP-D-mannose dehydratase; GDP-mannose 4,6 dehydratase; GDP-mannose 4,6-dehydratase; GMD; GMDS; SDR3E1; short chain dehydrogenase/reductase family 3E, member 1
Gene Symbols: GMDS
Molecular weight: 41,950 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
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GMD

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene