GIRK1 This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q21
Cellular Component:  cell surface; external side of plasma membrane; integral component of presynaptic membrane; parallel fiber to Purkinje cell synapse; T-tubule; voltage-gated potassium channel complex
Molecular Function:  G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding
Biological Process:  potassium ion import across plasma membrane; regulation of ion transmembrane transport; response to electrical stimulus
Reference #:  P63251 (UniProtKB)
Alt. Names/Synonyms: G protein-activated inward rectifier potassium channel 1; GIRK-1; GIRK1; inward rectifier K(+) channel Kir3.1; Kcnj3; KGA; KGB1; potassium channel inwarding rectifying channel subfamily J member 3; Potassium channel subunit Kir3.1 type 3; potassium channel subunit Kir3.1 type 3 delta; potassium channel, inwardly rectifying subfamily J member 3; potassium inwardly-rectifying channel, subfamily J, member 3
Gene Symbols: Kcnj3
Molecular weight: 56,573 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein