S1PR3 Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Belongs to the G-protein coupled receptor 1 family. Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 9q22.1
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  G protein-coupled receptor activity; integrin binding; lipid binding; protein binding; sphingosine-1-phosphate receptor activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; anatomical structure morphogenesis; cytokine production; G protein-coupled receptor signaling pathway; inflammatory response; negative regulation of establishment of endothelial barrier; Notch signaling pathway; positive regulation of cell proliferation; positive regulation of cytosolic calcium ion concentration; regulation of interleukin-1 beta production; sphingosine-1-phosphate receptor signaling pathway
Reference #:  Q99500 (UniProtKB)
Alt. Names/Synonyms: EDG-3; EDG3; Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ37523; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; LPB3; MGC71696; S1P receptor 3; S1P receptor Edg-3; S1P receptor EDG3; S1P3; S1PR3; Sphingosine 1-phosphate receptor 3; Sphingosine 1-phosphate receptor Edg-3; sphingosine-1-phosphate receptor 3
Gene Symbols: S1PR3
Molecular weight: 42,250 Da
Basal Isoelectric point: 9.78  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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