INMT Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. Catalyzes the N-methylation of tryptamine and structurally related compounds. Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC; EC; Methyltransferase
Chromosomal Location of human Ortholog: 7p14.3
Cellular Component:  cytosol
Molecular Function:  amine N-methyltransferase activity; protein binding; S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity; thioether S-methyltransferase activity
Biological Process:  amine metabolic process; methylation; response to toxic substance
Reference #:  O95050 (UniProtKB)
Alt. Names/Synonyms: Amine N-methyltransferase; Aromatic alkylamine N-methyltransferase; Arylamine N-methyltransferase; Indolamine N-methyltransferase; Indolethylamine N-methyltransferase; INMT; MGC125940; MGC125941; nicotine N-methyltransferase; TEMT; thioester S-methyltransferase-like; Thioether S-methyltransferase
Gene Symbols: INMT
Molecular weight: 28,891 Da
Basal Isoelectric point: 5.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB