|
TH iso3
Plays an important role in the physiology of adrenergic neurons. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Mainly expressed in the brain and adrenal glands. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle |
| Chromosomal Location of human Ortholog: 11p15.5 |
|
Cellular Component:
axon; cytoplasm; cytoplasmic side of plasma membrane; cytoplasmic vesicle; cytosol; dendrite; melanosome membrane; mitochondrion; neuron projection; nucleus; perikaryon; perinuclear region of cytoplasm; smooth endoplasmic reticulum; synaptic vesicle; terminal bouton
|
|
Molecular Function:
amino acid binding; dopamine binding; enzyme binding; ferric iron binding; ferrous iron binding; oxygen binding; protein binding; protein domain specific binding; tetrahydrobiopterin binding; tyrosine 3-monooxygenase activity
|
|
Biological Process:
aminergic neurotransmitter loading into synaptic vesicle; anatomical structure morphogenesis; animal organ morphogenesis; cellular response to alkaloid; cellular response to glucose stimulus; cellular response to growth factor stimulus; cellular response to manganese ion; cellular response to nicotine; cellular response to xenobiotic stimulus; cerebral cortex development; circadian sleep/wake cycle; dopamine biosynthetic process; dopamine biosynthetic process from tyrosine; eating behavior; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; fatty acid metabolic process; glycoside metabolic process; heart development; heart morphogenesis; hyaloid vascular plexus regression; isoquinoline alkaloid metabolic process; learning; locomotory behavior; mating behavior; memory; neurotransmitter biosynthetic process; norepinephrine biosynthetic process; phthalate metabolic process; phytoalexin metabolic process; pigmentation; regulation of heart contraction; response to activity; response to amphetamine; response to corticosterone; response to electrical stimulus; response to estradiol; response to ethanol; response to ether; response to herbicide; response to hypoxia; response to immobilization stress; response to isolation stress; response to light stimulus; response to lipopolysaccharide; response to nutrient levels; response to peptide hormone; response to pyrethroid; response to salt stress; response to zinc ion; social behavior; sphingolipid metabolic process; synaptic transmission, dopaminergic; terpene metabolic process; visual perception
|
|
Reference #:
P07101-3
(UniProtKB)
|
|
Alt. Names/Synonyms: dystonia 14; DYT14; DYT5b; TH; TH iso3; TY3H; TYH; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase
|
|
Gene Symbols: TH
|
|
Molecular weight:
55,612 Da
|
|
Basal Isoelectric point:
5.75
Predict pI for various phosphorylation states
|
|
CST Pathways:
GPCR Signaling to MAPKs
|
Parkinson's Disease
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
