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mGluR5 iso2
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. Belongs to the G-protein coupled receptor 3 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of rat Ortholog: 1q32 |
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Cellular Component:
astrocyte projection; cytoplasm; dendritic shaft; dendritic spine; glutamatergic synapse; neuron projection; plasma membrane; postsynapse; postsynaptic density membrane; postsynaptic membrane; Schaffer collateral - CA1 synapse; synapse
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Molecular Function:
A2A adenosine receptor binding; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; calmodulin binding; G protein-coupled receptor activity; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity; identical protein binding; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; PDZ domain binding; PLC activating G protein-coupled glutamate receptor activity; protein binding; protein tyrosine kinase binding
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; chemical synaptic transmission; cognition; desensitization of G protein-coupled receptor signaling pathway; G protein-coupled glutamate receptor signaling pathway; learning; learning or memory; locomotory behavior; modulation of chemical synaptic transmission; phosphatidylinositol-mediated signaling; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of MAPK cascade; positive regulation of protein tyrosine kinase activity; protein kinase C-activating G protein-coupled receptor signaling pathway; protein phosphorylation; regulation of DNA-templated transcription; regulation of intracellular calcium activated chloride channel activity; regulation of long-term neuronal synaptic plasticity; regulation of postsynaptic cytosolic calcium ion concentration; regulation of postsynaptic membrane potential; regulation of protein phosphorylation; regulation of synaptic transmission, glutamatergic; regulation of translational elongation; synapse organization; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
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Reference #:
P31424-2
(UniProtKB)
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Alt. Names/Synonyms: glutamate receptor, metabotropic 5; Gprc1e; Grm5; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; Mglur5; mGluR5 iso2
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Gene Symbols: Grm5
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Molecular weight:
128,290 Da
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Basal Isoelectric point:
7.58
Predict pI for various phosphorylation states
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