mGluR5 iso2 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. Belongs to the G-protein coupled receptor 3 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1q32
Cellular Component:  astrocyte projection; cytoplasm; dendritic shaft; dendritic spine; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; membrane; neuron projection; plasma membrane; postsynapse; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; Schaffer collateral - CA1 synapse
Molecular Function:  A2A adenosine receptor binding; calmodulin binding; G protein-coupled receptor activity; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; PDZ domain binding; PLC activating G protein-coupled glutamate receptor activity; protein binding; protein tyrosine kinase binding
Biological Process:  activation of MAPKKK activity; calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; chemical synaptic transmission; cognition; desensitization of G protein-coupled receptor signaling pathway; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; learning; learning or memory; locomotory behavior; modulation of age-related behavioral decline; negative regulation of locomotion; phosphatidylinositol-mediated signaling; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of long-term neuronal synaptic plasticity; positive regulation of protein tyrosine kinase activity; postsynaptic modulation of chemical synaptic transmission; protein kinase C-activating G protein-coupled receptor signaling pathway; protein phosphorylation; regulation of intracellular calcium activated chloride channel activity; regulation of long-term neuronal synaptic plasticity; regulation of postsynaptic cytosolic calcium ion concentration; regulation of postsynaptic membrane potential; regulation of protein phosphorylation; regulation of synaptic transmission, glutamatergic; regulation of transcription, DNA-templated; regulation of translational elongation; synapse organization; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Reference #:  P31424-2 (UniProtKB)
Alt. Names/Synonyms: glutamate receptor, metabotropic 5; Gprc1e; Grm5; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; Mglur5
Gene Symbols: Grm5
Molecular weight: 128,290 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
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mGluR5 iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene