Bcr iso2 Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity. Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component:  cell junction; cytosol; glutamatergic synapse; postsynaptic density; postsynaptic density, intracellular component; postsynaptic membrane; protein-containing complex; Schaffer collateral - CA1 synapse
Molecular Function:  ATP binding; GTPase activator activity; kinase activity; protein binding; protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity
Biological Process:  actin cytoskeleton organization; brain development; cellular response to lipopolysaccharide; definitive hemopoiesis; homeostasis of number of cells; inner ear morphogenesis; intracellular protein transmembrane transport; intracellular signal transduction; modulation of chemical synaptic transmission; negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; negative regulation of inflammatory response; negative regulation of neutrophil degranulation; negative regulation of reactive oxygen species metabolic process; negative regulation of respiratory burst; neuromuscular process controlling balance; platelet-derived growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of phagocytosis; protein autophosphorylation; protein phosphorylation; regulation of cell cycle; regulation of nitrogen compound metabolic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; regulation of vascular permeability; renal system process; signal transduction
Reference #:  P11274-2 (UniProtKB)
Alt. Names/Synonyms: BCR; Bcr iso2; BCR1; Breakpoint cluster region protein; D22S11; Renal carcinoma antigen NY-REN-26
Gene Symbols: BCR
Molecular weight: 137,729 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling
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Bcr iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein