mGluR5 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. Belongs to the G-protein coupled receptor 3 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 11q14.2-q14.3
Cellular Component:  cytoplasm; integral component of plasma membrane; neuron projection; plasma membrane; Schaffer collateral - CA1 synapse
Molecular Function:  G protein-coupled receptor activity; glutamate receptor activity; protein binding; protein tyrosine kinase activator activity; protein tyrosine kinase binding
Biological Process:  calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; chemical synaptic transmission; cognition; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; learning; learning or memory; locomotory behavior; modulation of age-related behavioral decline; phospholipase C-activating G protein-coupled glutamate receptor signaling pathway; positive regulation of protein tyrosine kinase activity; postsynaptic modulation of chemical synaptic transmission; regulation of intracellular calcium activated chloride channel activity; regulation of long-term neuronal synaptic plasticity; regulation of postsynaptic cytosolic calcium ion concentration; regulation of postsynaptic membrane potential; regulation of protein phosphorylation; regulation of translation; regulation of translational elongation; synapse organization
Reference #:  P41594 (UniProtKB)
Alt. Names/Synonyms: glutamate metabotropic receptor 5; glutamate receptor, metabotropic 5; GPRC1E; GRM5; Metabotropic glutamate receptor 5; mGlu5; MGLUR5; PPP1R86; protein phosphatase 1, regulatory subunit 86
Gene Symbols: GRM5
Molecular weight: 132,469 Da
Basal Isoelectric point: 8.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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