hnRNP P2 DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis. Belongs to the RRM TET family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding

Chromosomal Location of human Ortholog: 16p11.2

Cellular Component: cytoplasm; intracellular non-membrane-bounded organelle; nucleoplasm; nucleus

Molecular Function: chromatin binding; DNA binding; identical protein binding; metal ion binding; molecular condensate scaffold activity; mRNA 3'-UTR binding; protein binding; RNA binding; transcription coactivator activity; transcription coregulator activity

Biological Process: amyloid fibril formation; DNA-templated transcription; mRNA stabilization; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair via homologous recombination; protein homooligomerization; regulation of DNA-templated transcription; regulation of RNA splicing; regulation of transcription by RNA polymerase II; RNA splicing

Disease: Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia; Tremor, Hereditary Essential, 4

Reference #: P35637 (UniProtKB)

Alt. Names/Synonyms: 75 kDa DNA-pairing protein; ALS6; ETM4; FUS; FUS RNA binding protein; fus-like protein; FUS1; fused in sarcoma; fusion gene in myxoid liposarcoma; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; HNRNPP2; Oncogene FUS; Oncogene TLS; POMp75; RNA-binding protein FUS; TLS; Translocated in liposarcoma protein

Gene Symbols: FUS

Molecular weight: 53,426 Da

Basal Isoelectric point: 9.4 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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hnRNP P2

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