hnRNP P2 DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis. Belongs to the RRM TET family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component:  dendritic spine head; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; polysome
Molecular Function:  chromatin binding; DNA binding; estrogen receptor binding; identical protein binding; ionotropic glutamate receptor binding; metal ion binding; myosin V binding; protein binding; retinoid X receptor binding; thyroid hormone receptor binding; transcription coactivator activity
Biological Process:  cellular response to calcium ion; mRNA splicing, via spliceosome; positive regulation of double-strand break repair via homologous recombination; positive regulation of nucleic acid-templated transcription; protein homooligomerization; regulation of RNA splicing; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; RNA splicing
Disease: Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia; Tremor, Hereditary Essential, 4
Reference #:  P35637 (UniProtKB)
Alt. Names/Synonyms: 75 kDa DNA-pairing protein; ALS6; ETM4; FUS; FUS RNA binding protein; fus-like protein; FUS1; fused in sarcoma; fusion gene in myxoid liposarcoma; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; HNRNPP2; Oncogene FUS; Oncogene TLS; POMp75; RNA-binding protein FUS; TLS; Translocated in liposarcoma protein
Gene Symbols: FUS
Molecular weight: 53,426 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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hnRNP P2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein