GH receptor Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Belongs to the type I cytokine receptor family. Type 1 subfamily. Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of mouse Ortholog: 15 A1|15 1.84 cM
Cellular Component:  cell surface; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; external side of plasma membrane; extracellular region; extracellular space; growth hormone receptor complex; membrane; mitochondrion; neuronal cell body; nucleus; plasma membrane; receptor complex
Molecular Function:  cytokine binding; cytokine receptor activity; growth factor binding; growth hormone receptor activity; identical protein binding; lipid binding; peptide hormone binding; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; SH2 domain binding
Biological Process:  activation of Janus kinase activity; cellular response to hormone stimulus; cytokine-mediated signaling pathway; endocytosis; growth hormone receptor signaling pathway; hormone metabolic process; hormone-mediated signaling pathway; insulin-like growth factor receptor signaling pathway; localization; negative regulation of neuron death; positive regulation of MAP kinase activity; positive regulation of multicellular organism growth; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor signaling pathway via JAK-STAT; receptor signaling pathway via JAK-STAT; regulation of multicellular organism growth; response to estradiol; taurine metabolic process
Reference #:  P16882 (UniProtKB)
Alt. Names/Synonyms: AA986417; GH receptor; GH-binding protein; GHB; GHBP; Ghr; GHR/; GHR/BP; Growth hormone receptor; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein); growth hormone receptor/binding protein; growth hormone receptor/binding protein, high molecular weight; growth hormone receptor/binding protein, low molecular weight; Growth hormone-binding protein; Serum-binding protein; Somatotropin receptor
Gene Symbols: Ghr
Molecular weight: 72,783 Da
Basal Isoelectric point: 4.72  Predict pI for various phosphorylation states
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GH receptor

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene