GH receptor Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Belongs to the type I cytokine receptor family. Type 1 subfamily. Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 5p13.1-p12
Cellular Component:  cell surface; cytoplasmic ribonucleoprotein granule; cytosol; extracellular region; extracellular space; growth hormone receptor complex; integral component of membrane; integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function:  identical protein binding; peptide hormone binding; proline-rich region binding; protein binding; protein homodimerization activity; protein kinase binding
Biological Process:  activation of Janus kinase activity; activation of MAPK activity; cellular response to hormone stimulus; cytokine-mediated signaling pathway; endocytosis; growth hormone receptor signaling pathway; hormone metabolic process; insulin-like growth factor receptor signaling pathway; JAK-STAT cascade; JAK-STAT cascade involved in growth hormone signaling pathway; positive regulation of multicellular organism growth; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of multicellular organism growth; taurine metabolic process
Disease: Hypercholesterolemia, Familial; Laron Syndrome; Short Stature, Idiopathic, Autosomal
Reference #:  P10912 (UniProtKB)
Alt. Names/Synonyms: GH receptor; GH-binding protein; GHBP; GHIP; GHR; growth hormone binding protein; Growth hormone receptor; Growth hormone-binding protein; serum binding protein; Serum-binding protein; Somatotropin receptor
Gene Symbols: GHR
Molecular weight: 71,500 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
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GH receptor

Protein Structure Not Found.


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