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DARPP-32 iso2
Inhibitor of protein-phosphatase 1. Belongs to the protein phosphatase inhibitor 1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit |
| Chromosomal Location of human Ortholog: 17q12 |
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Cellular Component:
cytoplasm; cytosol; neuronal cell body; nucleus
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Molecular Function:
cAMP-dependent protein kinase inhibitor activity; protein binding; protein kinase inhibitor activity; protein phosphatase inhibitor activity; protein phosphatase regulator activity
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Biological Process:
behavioral response to cocaine; cellular response to cocaine; DNA-templated transcription; intracellular signal transduction; locomotory behavior; negative regulation of female receptivity; negative regulation of phosphoprotein phosphatase activity; response to amphetamine; response to morphine; signal transduction; visual learning
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Reference #:
Q9UD71-2
(UniProtKB)
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Alt. Names/Synonyms: DARPP-32; DARPP-32 iso2; DARPP32; dopamine and cAMP-regulated neuronal phosphoprotein 32; Dopamine- and cAMP-regulated neuronal phosphoprotein; PPP1R1B; PPR1B; protein phosphatase 1 regulatory inhibitor subunit 1B; Protein phosphatase 1 regulatory subunit 1B
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Gene Symbols: PPP1R1B
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Molecular weight:
18,738 Da
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Basal Isoelectric point:
4.24
Predict pI for various phosphorylation states
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CST Pathways:
Parkinson's Disease
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