EPS15 Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Oncoprotein; Vesicle
Chromosomal Location of Human Ortholog: 4|4 C7
Cellular Component:  aggresome; AP-2 adaptor complex; apical plasma membrane; basal plasma membrane; ciliary membrane; clathrin coat of coated pit; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytosol; early endosome; endosome; glutamatergic synapse; intracellular membrane-bounded organelle; membrane; plasma membrane; synapse
Molecular Function:  calcium ion binding; cargo receptor activity; identical protein binding; metal ion binding; polyubiquitin modification-dependent protein binding; protein binding; SH3 domain binding
Biological Process:  clathrin coat assembly; endocytic recycling; endocytosis; Golgi to endosome transport; positive regulation of receptor recycling; postsynaptic neurotransmitter receptor internalization; protein transport; receptor-mediated endocytosis of virus by host cell; regulation of cell proliferation; viral entry into host cell
Reference #:  P42567 (UniProtKB)
Alt. Names/Synonyms: 2410112D09Rik; epidermal growth factor pathway substrate 15; epidermal growth factor receptor pathway substrate 15; Epidermal growth factor receptor substrate 15; Eps15; OTTMUSP00000008654; Protein AF-1p; Protein Eps15; RP23-414M10.3
Gene Symbols: Eps15
Molecular weight: 98,471 Da
Basal Isoelectric point: 4.48  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene