RIMS1 Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes. Expressed in melanocytes (PubMed:23999003). Detected in brain and retina (PubMed:23999003). 13 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 6q13
Cellular Component:  cell junction; cytosol; plasma membrane; presynaptic active zone; presynaptic membrane
Molecular Function:  GTPase regulator activity; metal ion binding; protein binding; Rab GTPase binding
Biological Process:  acrosomal vesicle exocytosis; calcium ion regulated exocytosis; glutamate secretion; intracellular protein transport; membrane fusion; neurotransmitter secretion; positive regulation of dendrite extension; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of inhibitory postsynaptic potential; protein-containing complex assembly; regulated exocytosis; regulation of catalytic activity; regulation of neurotransmitter secretion; response to stimulus; secretion; synaptic vesicle exocytosis; visual perception
Disease: Cone-rod Dystrophy 7
Reference #:  Q86UR5 (UniProtKB)
Alt. Names/Synonyms: CORD7; KIAA0340; MGC167823; MGC176677; Rab-3-interacting molecule 1; Rab-3-interacting protein 2; rab3-interacting molecule 1; RAB3-interacting protein 2; RAB3IP2; regulating synaptic membrane exocytosis 1; Regulating synaptic membrane exocytosis protein 1; RIM; RIM 1; RIM1; RIMS1
Gene Symbols: RIMS1
Molecular weight: 189,073 Da
Basal Isoelectric point: 9.68  Predict pI for various phosphorylation states
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RIMS1

Protein Structure Not Found.


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