XPNPEP1 iso2 Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Belongs to the peptidase M24B family. Expressed in all tissues tested, including pancreas, heart, muscle, kidney, liver, lung and brain. Highest levels in pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.11.9; Protease
Chromosomal Location of human Ortholog: 10q25.1
Cellular Component:  cytoplasm; cytosol
Molecular Function:  aminopeptidase activity; manganese ion binding; metalloaminopeptidase activity; protein homodimerization activity
Biological Process:  bradykinin catabolic process; proteolysis
Reference #:  Q9NQW7-2 (UniProtKB)
Alt. Names/Synonyms: Aminoacylproline aminopeptidase; aminopeptidase P, cytosolic; APP1; Cytosolic aminopeptidase P; sAmp; Soluble aminopeptidase P; X-Pro aminopeptidase 1; X-prolyl aminopeptidase (aminopeptidase P) 1, soluble; X-prolyl aminopeptidase 1; X-prolyl aminopeptidase 1, soluble; Xaa-Pro aminopeptidase 1; XPNPEP; XPNPEP1; XPNPEP1 iso2; XPNPEPL; XPNPEPL1; XPP1
Gene Symbols: XPNPEP1
Molecular weight: 67,227 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Select Structure to View Below

XPNPEP1 iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene