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TAP
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. Belongs to the VDP/USO1/EDE1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Vesicle |
| Chromosomal Location of rat Ortholog: 14p22 |
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Cellular Component:
cytosol; endoplasmic reticulum; ER to Golgi transport vesicle membrane; exocytic vesicle; fibrillar center; Golgi apparatus; Golgi membrane; Golgi stack; perinuclear region of cytoplasm
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Molecular Function:
protein binding
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Biological Process:
ER to Golgi vesicle-mediated transport; Golgi organization; Golgi vesicle docking; intra-Golgi vesicle-mediated transport; intracellular protein transport; membrane fusion; regulation of cellular response to insulin stimulus; secretory granule localization; small GTPase mediated signal transduction; transcytosis; vesicle fusion with Golgi apparatus
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Reference #:
P41542
(UniProtKB)
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Alt. Names/Synonyms: General vesicular transport factor p115; Protein USO1 homolog; TAP; transcytosis associated protein; Transcytosis-associated protein; Uso1; USO1 homolog, vesicle docking protein (yeast); Vdp; vesicle docking protein, 115 kDa; Vesicle-docking protein
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Gene Symbols: Uso1
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Molecular weight:
107,162 Da
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Basal Isoelectric point:
4.87
Predict pI for various phosphorylation states
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