TAP General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. Belongs to the VDP/USO1/EDE1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of rat Ortholog: 14p22
Cellular Component:  cytosol; endoplasmic reticulum; ER to Golgi transport vesicle membrane; exocytic vesicle; fibrillar center; Golgi apparatus; Golgi membrane; Golgi stack; perinuclear region of cytoplasm
Molecular Function:  protein binding
Biological Process:  ER to Golgi vesicle-mediated transport; Golgi organization; Golgi vesicle docking; intra-Golgi vesicle-mediated transport; intracellular protein transport; membrane fusion; regulation of cellular response to insulin stimulus; secretory granule localization; small GTPase mediated signal transduction; transcytosis; vesicle fusion with Golgi apparatus
Reference #:  P41542 (UniProtKB)
Alt. Names/Synonyms: General vesicular transport factor p115; Protein USO1 homolog; TAP; transcytosis associated protein; Transcytosis-associated protein; Uso1; USO1 homolog, vesicle docking protein (yeast); Vdp; vesicle docking protein, 115 kDa; Vesicle-docking protein
Gene Symbols: Uso1
Molecular weight: 107,162 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene