MYST2 iso4 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1. Specifically represses AR-mediated transcription. Belongs to the MYST (SAS/MOZ) family. Ubiquitously expressed, with highest levels in testis. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component:  cytosol; histone acetyltransferase complex; nucleoplasm; nucleus
Molecular Function:  DNA replication origin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; transcription regulatory region DNA binding; zinc ion binding
Biological Process:  DNA replication; histone H3 acetylation; histone H4-K12 acetylation; histone H4-K5 acetylation; histone H4-K8 acetylation; internal peptidyl-lysine acetylation; positive regulation of histone H4 acetylation; positive regulation of protein localization to nucleus; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to actinomycin D; response to anisomycin; response to dithiothreitol; response to hydroxyurea; response to sorbitol; stress-activated protein kinase signaling cascade
Reference #:  O95251-4 (UniProtKB)
Alt. Names/Synonyms: HBO1; HBOa; Histone acetyltransferase binding to ORC1; Histone acetyltransferase KAT7; histone acetyltransferase MYST2; K(lysine) acetyltransferase 7; KAT7; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST histone acetyltransferase 2; MYST-2; MYST2; MYST2 iso4; ZC2HC7
Gene Symbols: KAT7
Molecular weight: 66,947 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
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MYST2 iso4

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein