HADHSC iso2 Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA. Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. Expressed in liver, kidney, pancreas, heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Oxidoreductase
Chromosomal Location of Human Ortholog: 4q25
Cellular Component:  cytoplasm; mitochondrial matrix; mitochondrion; nucleoplasm
Molecular Function:  3-hydroxyacyl-CoA dehydrogenase activity; NAD+ binding
Biological Process:  fatty acid beta-oxidation; negative regulation of insulin secretion; positive regulation of cold-induced thermogenesis; response to activity; response to drug; response to insulin
Reference #:  Q16836-2 (UniProtKB)
Alt. Names/Synonyms: HAD; HADHSC; HADHSC iso2; HCDH; hydroxyacyl-CoA dehydrogenase; Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; SCHAD; Short-chain 3-hydroxyacyl-CoA dehydrogenase
Gene Symbols: HADH
Molecular weight: 42,140 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene