MRCKB Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. Expressed in all tissues examined, with high levels in heart, brain, placenta and lung. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC 2.7.11.1; GEK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12 F1|12 60.94 cM
Cellular Component:  actomyosin; cell junction; cell projection; cytoplasm; cytoskeleton; membrane; plasma membrane
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; Rho GTPase binding; transferase activity
Biological Process:  actin cytoskeleton organization; actomyosin structure organization; cell migration; intracellular signal transduction; peptidyl-threonine phosphorylation; phosphorylation; protein phosphorylation
Reference #:  Q7TT50 (UniProtKB)
Alt. Names/Synonyms: CDC42 binding protein kinase beta; CDC42-binding protein kinase beta; Cdc42bpb; DMPK-like beta; Kiaa1124; MRCK beta; MRCKB; myotonic dystrophy kinase related CDC42 binding kinase beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; myotonic dystrophy protein kinase like beta; Myotonic dystrophy protein kinase-like beta; Serine/threonine-protein kinase MRCK beta
Gene Symbols: Cdc42bpb
Molecular weight: 194,753 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
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MRCKB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene