CAMK1D a calcium/calmodulin-dependent S/T protein kinase of the CAMK group. Binding of calmodulin is thought to result in a conformational change and can lead to subsequent activation through phosphorylation by CAMKK1 and CAMKK2. Can be activated by CAMKK1 in a calcium-independent manner. Its Ca(2+)/CaM-dependent activity is enhanced 30-fold in vitro by phosphorylation at Thr180 by CaMKK1. Broadly expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. May regulate calcium-mediated granulocyte function. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta and probably CREB1. Expression increases upon treatment of EC cells with DMSO and retinoic acid. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK1 family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 2|2 A1
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; catalytic activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  inflammatory response; metabolic process; negative regulation of apoptotic process; nervous system development; phosphorylation; positive regulation of apoptotic process; positive regulation of CREB transcription factor activity; positive regulation of neuron projection development; positive regulation of neutrophil chemotaxis; positive regulation of phagocytosis; positive regulation of respiratory burst; protein phosphorylation; regulation of dendrite development; regulation of granulocyte chemotaxis
Reference #:  Q8BW96 (UniProtKB)
Alt. Names/Synonyms: A630059D12Rik; calcium/calmodulin-dependent protein kinase 1D; calcium/calmodulin-dependent protein kinase ID; Calcium/calmodulin-dependent protein kinase type 1D; CaM kinase I delta; CaM kinase ID; CaM-KI delta; Camk1d; CaMKI delta; CaMKI-like protein kinase; CaMKIdelta; CKLiK; E030025C11Rik; KCC1D; mCKLiK; OTTMUSP00000011831
Gene Symbols: Camk1d
Molecular weight: 42,919 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein