osteopontin iso2 Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. Belongs to the osteopontin family. Bone. Found in plasma. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component:  cell projection; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus; perinuclear region of cytoplasm
Molecular Function:  cytokine activity; integrin binding; protein binding
Biological Process:  androgen catabolic process; biomineral tissue development; cell adhesion; cellular protein metabolic process; cellular response to testosterone stimulus; decidualization; embryo implantation; extracellular matrix organization; inflammatory response; negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of estradiol secretion; positive regulation of transcription, DNA-templated; post-translational protein modification; regulation of signaling receptor activity; response to steroid hormone; response to vitamin D
Reference #:  P10451-2 (UniProtKB)
Alt. Names/Synonyms: BNSP; Bone sialoprotein 1; Nephropontin; OPN; Osteopontin; osteopontin iso2; OSTP; Secreted phosphoprotein 1; SPP-1; SPP1; Urinary stone protein; Uropontin
Gene Symbols: SPP1
Molecular weight: 33,844 Da
Basal Isoelectric point: 4.39  Predict pI for various phosphorylation states
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osteopontin iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene