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INCENP
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin. Activates AURKB and AURKC. Required for localization of CBX5 to mitotic centromeres. Controls the kinetochore localization of BUB1. Belongs to the INCENP family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; EC 2.7.11.1 |
| Chromosomal Location of mouse Ortholog: 19 A|19 6.1 cM |
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Cellular Component:
central element; chromocenter; chromosome; chromosome passenger complex; chromosome, centromeric region; cytoplasm; cytoskeleton; cytosol; kinetochore; lateral element; meiotic spindle midzone; microtubule; microtubule cytoskeleton; midbody; nuclear body; nucleoplasm; nucleus; pericentric heterochromatin; protein-containing complex; spindle; synaptonemal complex
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Molecular Function:
molecular function activator activity
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Biological Process:
cell cycle; cell division; chromosome segregation; meiotic spindle midzone assembly; metaphase plate congression; mitotic cell cycle; mitotic cytokinesis; mitotic spindle midzone assembly; mitotic spindle organization; positive regulation of attachment of mitotic spindle microtubules to kinetochore; positive regulation of mitotic cell cycle spindle assembly checkpoint; positive regulation of mitotic cytokinesis; positive regulation of mitotic sister chromatid separation; positive regulation of protein phosphorylation; protein phosphorylation
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Reference #:
Q9WU62
(UniProtKB)
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Alt. Names/Synonyms: 2700067E22Rik; AU019509; C130081E20; C77457; INCE; Incenp; Inner centromere protein
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Gene Symbols: Incenp
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Molecular weight:
101,209 Da
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Basal Isoelectric point:
9.58
Predict pI for various phosphorylation states
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