p70S6K iso2 an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; Translation; p70 subfamily
Chromosomal Location of Human Ortholog: 17q23.1
Cellular Component:  cell junction; cytosol; mitochondrial outer membrane; mitochondrion; neuron projection; nucleoplasm; synapse
Molecular Function:  ATP binding; kinase activity; protein binding; protein kinase activity; protein serine/threonine/tyrosine kinase activity
Biological Process:  apoptotic process; cellular response to growth factor stimulus; G1/S transition of mitotic cell cycle; long-chain fatty acid import; negative regulation of apoptotic process; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; phosphatidylinositol-mediated signaling; positive regulation of mitotic cell cycle; positive regulation of translation; positive regulation of translational initiation; response to nutrient levels; signal transduction; TOR signaling
Reference #:  P23443-2 (UniProtKB)
Alt. Names/Synonyms: 70 kDa ribosomal protein S6 kinase 1; KS6B1; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70-S6K 1; P70S6K1; PS6K; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kDa, polypeptide 1; RPS6KB1; S6K; S6K-beta-1; S6K1; serine/threonine kinase 14 alpha; Serine/threonine-protein kinase 14A; STK14A
Gene Symbols: RPS6KB1
Molecular weight: 56,189 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K
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p70S6K iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene