mGluR4 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 20p12
Cellular Component:  cytoplasmic vesicle; dendritic shaft; glutamatergic synapse; integral component of plasma membrane; integral component of presynaptic active zone membrane; neuron projection; parallel fiber to Purkinje cell synapse; presynaptic active zone membrane; presynaptic membrane; terminal bouton
Molecular Function:  calcium-dependent protein binding; calmodulin binding; G protein-coupled receptor activity; glutamate receptor activity; protein binding
Biological Process:  activation of MAPK activity; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; chemical synaptic transmission; G protein-coupled glutamate receptor signaling pathway; gamma-aminobutyric acid secretion; learning; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of synaptic transmission; neuron projection development; positive regulation of MAPK cascade; regulation of neuron apoptotic process; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle exocytosis; synaptic transmission, GABAergic; synaptic transmission, glutamatergic
Reference #:  P31423 (UniProtKB)
Alt. Names/Synonyms: glutamate receptor, metabotropic 4; Gprc1d; Grm4; Metabotropic glutamate receptor 4; Mglur4
Gene Symbols: Grm4
Molecular weight: 101,819 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene