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mGluR4
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of rat Ortholog: 20p12 |
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Cellular Component:
cerebellar granule cell to Purkinje cell synapse; cytoplasmic vesicle; dendritic shaft; glutamatergic synapse; neuron projection; parallel fiber to Purkinje cell synapse; plasma membrane; presynaptic active zone membrane; terminal bouton
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Molecular Function:
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; calcium-dependent protein binding; calmodulin binding; G protein-coupled receptor activity; glutamate receptor activity; protein binding
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; chemical synaptic transmission; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; gamma-aminobutyric acid secretion; learning; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of synaptic transmission; neuron projection development; positive regulation of MAPK cascade; presynaptic modulation of chemical synaptic transmission; regulation of neuron apoptotic process; regulation of synaptic transmission, glutamatergic; synaptic transmission, GABAergic; synaptic transmission, glutamatergic
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Reference #:
P31423
(UniProtKB)
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Alt. Names/Synonyms: glutamate receptor, metabotropic 4; Gprc1d; Grm4; Metabotropic glutamate receptor 4; Mglur4
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Gene Symbols: Grm4
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Molecular weight:
101,819 Da
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Basal Isoelectric point:
9.06
Predict pI for various phosphorylation states
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