mGluR1 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Belongs to the G-protein coupled receptor 3 family. Detected in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10|10 A1
Cellular Component:  axon; dendrite; dendritic spine; G protein-coupled receptor dimeric complex; G protein-coupled receptor homodimeric complex; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic density membrane; integral component of postsynaptic membrane; membrane; neuron projection; neuronal cell body; nucleus; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynaptic membrane; Schaffer collateral - CA1 synapse
Molecular Function:  estrogen receptor binding; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; G protein-coupled receptor activity; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity; identical protein binding; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; PLC activating G protein-coupled glutamate receptor activity; protein binding
Biological Process:  activation of MAPK activity; activation of MAPKK activity; calcium-mediated signaling; cellular response to electrical stimulus; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; locomotory behavior; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; regulation of MAPK cascade; regulation of sensory perception of pain; regulation of synaptic transmission, glutamatergic; sensory perception of pain; signal transduction
Reference #:  P97772 (UniProtKB)
Alt. Names/Synonyms: 4930455H15Rik; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; glutamate receptor, metabotropic 1; Gm10828; Gpr; Gprc1a; Grm; Grm1; Metabotropic glutamate receptor 1; MGC90744; mGlu; Mglur1; nmf37; nmf373; OTTMUSP00000017441; rcw; wobl
Gene Symbols: Grm1
Molecular weight: 133,212 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene