mGluR1 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Belongs to the G-protein coupled receptor 3 family. Detected in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 6q24.3
Cellular Component:  dendrite; G protein-coupled receptor dimeric complex; G protein-coupled receptor homodimeric complex; glutamatergic synapse; integral component of plasma membrane; nucleus; plasma membrane; Schaffer collateral - CA1 synapse
Molecular Function:  G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; G protein-coupled receptor activity; glutamate receptor activity; protein binding
Biological Process:  activation of MAPK activity; activation of MAPKK activity; cellular response to electrical stimulus; chemical synaptic transmission; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; locomotory behavior; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; regulation of postsynaptic cytosolic calcium ion concentration; regulation of postsynaptic membrane potential; regulation of sensory perception of pain; sensory perception of pain
Disease: Spinocerebellar Ataxia 44; Spinocerebellar Ataxia, Autosomal Recessive 13
Reference #:  Q13255 (UniProtKB)
Alt. Names/Synonyms: glutamate metabotropic receptor 1; glutamate receptor, metabotropic 1; GPRC1A; GRM1; GRM1A; Metabotropic glutamate receptor 1; mGlu1; MGLUR1; MGLUR1A; PPP1R85; protein phosphatase 1, regulatory subunit 85; SCA44; SCAR13
Gene Symbols: GRM1
Molecular weight: 132,357 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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