mGluR2 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family. Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 8q32
Cellular Component:  axon; cell junction; dendrite; integral component of plasma membrane; integral component of postsynaptic membrane; neuron projection; presynaptic membrane
Molecular Function:  calcium channel regulator activity; glutamate receptor activity; group II metabotropic glutamate receptor activity; protein binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; chemical synaptic transmission; G protein-coupled glutamate receptor signaling pathway; glutamate homeostasis; glutamate secretion; regulation of neurotransmitter secretion; regulation of synaptic transmission, glutamatergic
Reference #:  P31421 (UniProtKB)
Alt. Names/Synonyms: glutamate receptor, metabotropic 2; Gprc1b; Grm2; Metabotropic glutamate receptor 2; Mglur2
Gene Symbols: Grm2
Molecular weight: 95,774 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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mGluR2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene