RIMS1 a Rab effector protein involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short- term synaptic plasticity. Binds UNC13, SNAP25, SYT1, CACNA1B, and activated RAB3A, RAB3B and RAB3D. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions. Defects are a cause of autosomal dominant cone-rod dystrophy (CORD7). Eight splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 9q13
Cellular Component:  cell junction; cytoskeleton of presynaptic active zone; GABA-ergic synapse; glutamatergic synapse; inhibitory synapse; membrane; plasma membrane; postsynaptic density; presynaptic active zone; presynaptic active zone cytoplasmic component; presynaptic membrane; synapse; vesicle
Molecular Function:  ion channel binding; metal ion binding; protein binding; protein kinase binding; Rab GTPase binding; SH3 domain binding; structural constituent of presynaptic active zone
Biological Process:  acrosomal vesicle exocytosis; calcium ion-regulated exocytosis of neurotransmitter; cell differentiation; exocytosis; intracellular protein transport; long-term synaptic potentiation; neurotransmitter secretion; positive regulation of dendrite extension; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of inhibitory postsynaptic potential; positive regulation of synaptic transmission; positive regulation of synaptic vesicle fusion to presynaptic active zone membrane; positive regulation of synaptic vesicle priming; protein-containing complex assembly; regulation of long-term neuronal synaptic plasticity; regulation of membrane potential; regulation of synaptic plasticity; regulation of synaptic vesicle exocytosis; spontaneous neurotransmitter secretion; synaptic vesicle docking; synaptic vesicle priming
Reference #:  Q9JIR4 (UniProtKB)
Alt. Names/Synonyms: Rab-3-interacting molecule 1; Rab3 effector; rab3-interacting molecule 1; regulating synaptic membrane exocytosis 1; Regulating synaptic membrane exocytosis protein 1; RIM 1; Rim1; Rim1b protein; Rims1
Gene Symbols: Rims1
Molecular weight: 179,655 Da
Basal Isoelectric point: 9.62  Predict pI for various phosphorylation states
Select Structure to View Below

RIMS1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene