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N-CoR1 iso2
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 11|11 B2 |
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Cellular Component:
chromatin; cytoplasm; cytosol; histone deacetylase complex; mitotic spindle; nucleoplasm; nucleus; perinuclear region of cytoplasm; transcription regulator complex; transcription repressor complex
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Molecular Function:
chromatin binding; DNA binding; histone deacetylase binding; histone deacetylase regulator activity; nuclear estrogen receptor binding; nuclear receptor binding; nuclear retinoic acid receptor binding; nuclear retinoid X receptor binding; nuclear thyroid hormone receptor binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription corepressor activity
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Biological Process:
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; cellular response to Thyroglobulin triiodothyronine; cholesterol homeostasis; chromatin organization; circadian regulation of gene expression; definitive erythrocyte differentiation; epidermis development; establishment of skin barrier; gene expression; in utero embryonic development; locomotor rhythm; negative regulation of androgen receptor signaling pathway; negative regulation of DNA-templated transcription; negative regulation of fatty acid metabolic process; negative regulation of gene expression; negative regulation of glycolytic process; negative regulation of JNK cascade; negative regulation of miRNA transcription; negative regulation of phosphatidylinositol 3-kinase signaling; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; protein stabilization; regulation of multicellular organism growth; regulation of thyroid hormone mediated signaling pathway; regulation of transcription by RNA polymerase II; rhythmic process; spindle assembly; T cell differentiation in thymus; thalamus development
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Reference #:
Q60974-2
(UniProtKB)
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Alt. Names/Synonyms: 5730405M06Rik; A230020K14Rik; mKIAA1047; N-CoR; N-CoR1; N-CoR1 iso2; Ncor1; nuclear receptor co-repressor 1; Nuclear receptor corepressor 1; Retinoid X receptor-interacting protein 13; RIP13; Rxr; Rxrip13
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Gene Symbols: Ncor1
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Molecular weight:
266,518 Da
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Basal Isoelectric point:
6.31
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Protein Acetylation
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