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CDC20
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. Belongs to the WD repeat CDC20/Fizzy family. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Ubiquitin conjugating system |
| Chromosomal Location of rat Ortholog: 5q36 |
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Cellular Component:
anaphase-promoting complex; centrosome; cytosol; kinetochore; mitotic checkpoint complex; nucleoplasm; perinuclear region of cytoplasm; protein-containing complex; spindle pole
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Molecular Function:
anaphase-promoting complex binding; histone deacetylase binding; protein binding; ubiquitin ligase activator activity; ubiquitin-protein transferase activator activity
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Biological Process:
anaphase-promoting complex-dependent catabolic process; cell division; mitotic sister chromatid cohesion; mitotic spindle assembly; negative regulation of ubiquitin-protein transferase activity; positive regulation of anaphase-promoting complex-dependent catabolic process; positive regulation of cell population proliferation; positive regulation of meiotic cell cycle process involved in oocyte maturation; positive regulation of mitotic metaphase/anaphase transition; positive regulation of synapse maturation; positive regulation of synaptic plasticity; positive regulation of ubiquitin protein ligase activity; protein ubiquitination; regulation of dendrite development; regulation of meiotic nuclear division
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Reference #:
Q62623
(UniProtKB)
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Alt. Names/Synonyms: Cdc20; cell cycle protein p55CDC; cell division cycle 20 homolog (S. cerevisiae); Cell division cycle protein 20 homolog; MGC93111; p55CDC
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Gene Symbols: Cdc20
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Molecular weight:
54,829 Da
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Basal Isoelectric point:
9.26
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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