Kv4.2 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons. This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5. Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation. Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily. Detected in ovary, in corpus luteum and in granulosa and theca cells in the follicle (at protein level) (PubMed:15991246). Highly expressed throughout the brain (PubMed:10551270, PubMed:10729221). Detected in amygdala, caudate nucleus, cerebellum, hippocampus, substantia nigra and thalamus (PubMed:10551270, PubMed:10729221). Expression is not detectable or very low in heart, kidney, liver, lung, pancreas and skeletal muscle (PubMed:10551270, PubMed:10729221). Not detectable in human heart atrium (PubMed:12395204). Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6 A2-A3.1|6 8.49 cM
Cellular Component:  caveola; cell junction; cell projection; dendrite; dendritic spine; GABA-ergic synapse; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of postsynaptic specialization membrane; intrinsic component of plasma membrane; membrane; neuron projection; neuronal cell body; neuronal cell body membrane; perinuclear endoplasmic reticulum; plasma membrane; plasma membrane raft; postsynaptic density; postsynaptic membrane; potassium channel complex; sarcolemma; synapse; T-tubule; voltage-gated potassium channel complex
Molecular Function:  A-type (transient outward) potassium channel activity; ion channel activity; metal ion binding; potassium channel activity; protein binding; protein heterodimerization activity; voltage-gated ion channel activity; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated potassium channel activity
Biological Process:  action potential; cardiac muscle cell action potential; cellular response to hypoxia; ion transport; locomotor rhythm; neuronal action potential; potassium ion transmembrane transport; potassium ion transport; protein heterooligomerization; protein homooligomerization; regulation of ion transmembrane transport; sensory perception of pain; transmembrane transport
Reference #:  Q9Z0V2 (UniProtKB)
Alt. Names/Synonyms: AI839615; AW555701; Kcnd2; Kiaa1044; Kv4.2; mKIAA1044; potassium channel Kv4.2; Potassium voltage-gated channel subfamily D member 2; potassium voltage-gated channel, Shal-related family, member 2; R75121; Voltage-gated potassium channel subunit Kv4.2
Gene Symbols: Kcnd2
Molecular weight: 70,577 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene