ICAM1
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. Belongs to the immunoglobulin superfamily. ICAM family. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral |
Chromosomal Location of mouse Ortholog: 9 A3|9 7.69 cM |
Cellular Component:
cell surface; external side of plasma membrane; extracellular exosome; extracellular space; immunological synapse; membrane; membrane raft
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Molecular Function:
integrin binding; protein-containing complex binding
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Biological Process:
acute inflammatory response to antigenic stimulus; adhesion of symbiont to host; cell adhesion; cell adhesion mediated by integrin; cell-cell adhesion; cellular response to amyloid-beta; cellular response to glucose stimulus; cellular response to leukemia inhibitory factor; establishment of endothelial barrier; establishment of endothelial intestinal barrier; establishment of Sertoli cell barrier; leukocyte cell-cell adhesion; negative regulation of calcium ion transport; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of actin filament polymerization; positive regulation of cellular extravasation; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vasoconstriction; receptor-mediated virion attachment to host cell; regulation of cell shape; regulation of ruffle assembly; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; T cell antigen processing and presentation; T cell extravasation
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Reference #:
P13597
(UniProtKB)
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Alt. Names/Synonyms: CD54; Icam; ICAM-1; Icam1; Intercellular adhesion molecule 1; Ly-4; Ly-47; MAL; MALA-2; MGC6195; MyD10
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Gene Symbols: Icam1
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Molecular weight:
58,844 Da
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Basal Isoelectric point:
5.79
Predict pI for various phosphorylation states
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