SOCS3 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST. Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 11|11 E2
Cellular Component:  cytoplasm; phosphatidylinositol 3-kinase complex
Molecular Function:  1-phosphatidylinositol-3-kinase regulator activity; phosphotyrosine residue binding; protein binding
Biological Process:  branching involved in labyrinthine layer morphogenesis; cellular response to leukemia inhibitory factor; intracellular signal transduction; JAK-STAT cascade; negative regulation of apoptotic process; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of signal transduction; negative regulation of tyrosine phosphorylation of STAT protein; phosphatidylinositol phosphorylation; placenta blood vessel development; positive regulation of cell differentiation; regulation of cell differentiation; regulation of growth; regulation of protein phosphorylation; signal transduction; spongiotrophoblast differentiation; trophoblast giant cell differentiation
Reference #:  O35718 (UniProtKB)
Alt. Names/Synonyms: Cis; CIS-3; Cis3; Cish3; cytokine inducible SH2-containing protein 3; Cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; EF-10; Ef10; OTTMUSP00000003963; Protein EF-10; SOC; SOCS-3; Socs3; SSI-3; Ssi3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3
Gene Symbols: Socs3
Molecular weight: 24,776 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene