Catalase Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Belongs to the catalase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; Apoptosis; EC; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase
Chromosomal Location of mouse Ortholog: 2 E2|2 54.43 cM
Cellular Component:  catalase complex; cytoplasm; cytosol; extracellular space; intracellular membrane-bounded organelle; mitochondrion; peroxisomal membrane; peroxisome; protein-containing complex
Molecular Function:  aminoacylase activity; antioxidant activity; catalase activity; enzyme binding; heme binding; identical protein binding; metal ion binding; NADP binding; oxidoreductase activity; oxidoreductase activity, acting on peroxide as acceptor; peroxidase activity; protein homodimerization activity
Biological Process:  aerobic respiration; cellular detoxification of hydrogen peroxide; cholesterol metabolic process; hemoglobin metabolic process; hydrogen peroxide catabolic process; kidney development; negative regulation of apoptotic process; negative regulation of NF-kappaB transcription factor activity; positive regulation of cell division; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphatidylinositol 3-kinase signaling; response to hydrogen peroxide; response to hypoxia; response to oxidative stress; response to reactive oxygen species; triglyceride metabolic process; ureteric bud development; UV protection
Reference #:  P24270 (UniProtKB)
Alt. Names/Synonyms: 2210418N07; Cas; Cas-1; Cas1; Cat; CATA; Catalase; catalase 1; Cs-; Cs-1; OTTMUSP00000015802
Gene Symbols: Cat
Molecular weight: 59,795 Da
Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein