Catalase Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Belongs to the catalase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; Apoptosis; EC; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 11p13
Cellular Component:  cytosol; endoplasmic reticulum; extracellular region; ficolin-1-rich granule lumen; Golgi apparatus; intracellular membrane-bounded organelle; lysosome; mitochondrial intermembrane space; peroxisomal matrix; peroxisomal membrane; peroxisome; plasma membrane; secretory granule lumen
Molecular Function:  aminoacylase activity; antioxidant activity; catalase activity; enzyme binding; heme binding; identical protein binding; metal ion binding; NADP binding; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; signaling receptor binding
Biological Process:  aerobic respiration; aging; cellular oxidant detoxification; cellular response to growth factor stimulus; cellular response to oxidative stress; cholesterol metabolic process; hemoglobin metabolic process; hydrogen peroxide catabolic process; negative regulation of apoptotic process; negative regulation of NF-kappaB transcription factor activity; neutrophil degranulation; positive regulation of cell division; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphatidylinositol 3-kinase signaling; protein homotetramerization; protein targeting to peroxisome; protein tetramerization; response to activity; response to cadmium ion; response to estradiol; response to ethanol; response to fatty acid; response to hyperoxia; response to hypoxia; response to inactivity; response to insulin; response to L-ascorbic acid; response to lead ion; response to light intensity; response to ozone; response to phenylpropanoid; response to reactive oxygen species; response to vitamin A; response to vitamin E; triglyceride metabolic process; ureteric bud development; UV protection
Disease: Acatalasemia
Reference #:  P04040 (UniProtKB)
Alt. Names/Synonyms: CAT; CATA; Catalase; MGC138422; MGC138424
Gene Symbols: CAT
Molecular weight: 59,756 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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