STAR Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. May interact with TSPO. Expressed in gonads, adrenal cortex and kidney. Note: This description may include information from UniProtKB.
Protein type: Carrier; Lipid-binding; Mitochondrial
Chromosomal Location of Human Ortholog: 8 A2|8 14.17 cM
Cellular Component:  cytosol; mitochondrial crista; mitochondrial intermembrane space; mitochondrion; neuron projection; neuronal cell body
Molecular Function:  cholesterol binding; cholesterol transporter activity; lipid binding
Biological Process:  bile acid biosynthetic process; cellular lipid metabolic process; cellular response to interferon-alpha; estrogen biosynthetic process; glucocorticoid metabolic process; intracellular cholesterol transport; lipid transport; negative regulation of neuron apoptotic process; positive regulation of bile acid biosynthetic process; positive regulation of gene expression; positive regulation of neurogenesis; regulation of neuronal synaptic plasticity; regulation of steroid biosynthetic process; steroid biosynthetic process
Reference #:  P51557 (UniProtKB)
Alt. Names/Synonyms: AV363654; D8Ertd419e; Luteinizing hormone-induced protein; StAR; StARD1; START domain-containing protein 1; steroidogenic acute regulatory protein; Steroidogenic acute regulatory protein, mitochondrial
Gene Symbols: Star
Molecular weight: 31,626 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene