DDEF1 Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 15|15 D1
Cellular Component:  cytoplasm; cytosol; dendritic spine; glutamatergic synapse; membrane; podosome
Molecular Function:  GTPase activator activity; metal ion binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein binding
Biological Process:  cell projection organization; cilium assembly; negative regulation of dendritic spine development; positive regulation of GTPase activity; positive regulation of membrane tubulation; regulation of postsynapse organization
Reference #:  Q9QWY8 (UniProtKB)
Alt. Names/Synonyms: 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; ArfGAP with SH# domain, ankyrin repeat and PH domain1; ArfGAP with SH3 domain, ankyrin repeat and PH domain1; Asap1; AV239055; Ddef1; DEF-1; development and differentiation enhancing; Development and differentiation-enhancing factor 1; Differentiation-enhancing factor 1; Kiaa1249; mKIAA1249; PAP; PIP2-dependent ARF1 GAP; s19; Shag1
Gene Symbols: Asap1
Molecular weight: 127,421 Da
Basal Isoelectric point: 7.54  Predict pI for various phosphorylation states
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DDEF1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene